Seroatlas · Human Serome Atlas

IGHV5-10-1

Immunoglobulin heavy variable 5-10-1

Also known as: HV5X1_HUMAN, IGHV5-A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0J9YXX1
Gene: IGHV5-10-1
Ensembl: ENSG00000282651
Chromosome: 14
Canonical length: 117 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0J9YXX1|IGHV5-10-1
     1  MGSTAILALL LAVLQGVCAE VQLVQSGAEV KKPGESLRIS CKGSGYSFTS YWISWVRQMP
    61  GKGLEWMGRI DPSDSYTNYS PSFQGHVTIS ADKSISTAYL QWSSLKASDT AMYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV5-10-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 529 nTPM

Expression across tissuesHPA

Tissue

tonsil: 529 nTPM
rectum: 296 nTPM
colon: 256 nTPM
appendix: 217 nTPM
spleen: 192 nTPM
urinary bladder: 185 nTPM

Single-cell type

plasma cells: 4.7 nCPM
salivary myoepithelial cells: 0.3 nCPM
erythrocytes: 0.2 nCPM
b-cells: 0.1 nCPM
cdc: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

memory B-cell: 75 nTPM
naive B-cell: 67 nTPM
neutrophil: 4.6 nTPM
total PBMC: 3.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
pons: 0.4 nTPM
medulla oblongata: 0.3 nTPM
choroid plexus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV5-10-1 as an antibody target. Whether an autoantibody or antibody against IGHV5-10-1 could matter depends on whether native IGHV5-10-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV5-10-1 is annotated at the cell surface, where native IGHV5-10-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV5-10-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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