IGHV4-61
Immunoglobulin heavy variable 4-61
Also known as: HV461_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH41
- Gene
- IGHV4-61
- Ensembl
- ENSG00000211970
- Chromosome
- 14
- Canonical length
- 118 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
118 residues, UniProt reviewed canonical sequence.
>A0A0C4DH41|IGHV4-61
1 MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSVSS GSYYWSWIRQ
61 PPGKGLEWIG YIYYSGSTNY NPSLKSRVTI SVDTSKNQFS LKLSSVTAAD TAVYYCARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV4-61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 360 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 360 nTPM
- colon: 193 nTPM
- duodenum: 174 nTPM
- spleen: 171 nTPM
- stomach: 134 nTPM
- rectum: 114 nTPM
Single-cell type
- plasma cells: 4 nCPM
- mucous neck cells: 1.6 nCPM
- foveolar cells: 1.2 nCPM
- gastric chief cells: 1.1 nCPM
- b-cells: 0.1 nCPM
- cdc: 0.1 nCPM
Immune cell
- memory B-cell: 39 nTPM
- naive B-cell: 26 nTPM
- total PBMC: 4.6 nTPM
- plasmacytoid DC: 0.7 nTPM
- classical monocyte: 0.3 nTPM
- memory CD8 T-cell: 0.1 nTPM
Brain region
- medulla oblongata: 0.6 nTPM
- spinal cord: 0.6 nTPM
- pons: 0.5 nTPM
- cerebral cortex: 0.4 nTPM
- choroid plexus: 0.3 nTPM
- hypothalamus: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV4-61 as an antibody target. Whether an autoantibody or antibody against IGHV4-61 could matter depends on whether native IGHV4-61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV4-61 is annotated at the cell surface, where native IGHV4-61 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV4-61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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