IGHV4-59
Immunoglobulin heavy variable 4-59
Also known as: HV459_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01825
- Gene
- IGHV4-59
- Ensembl
- ENSG00000224373
- Chromosome
- 14
- Canonical length
- 116 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
116 residues, UniProt reviewed canonical sequence.
>P01825|IGHV4-59
1 MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGGSISS YYWSWIRQPP
61 GKGLEWIGYI YYSGSTNYNP SLKSRVTISV DTSKNQFSLK LSSVTAADTA VYYCARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV4-59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 851 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 851 nTPM
- urinary bladder: 660 nTPM
- colon: 492 nTPM
- spleen: 439 nTPM
- rectum: 426 nTPM
- duodenum: 283 nTPM
Single-cell type
- plasma cells: 25 nCPM
- gastric chief cells: 16 nCPM
- parietal cells: 7.1 nCPM
- foveolar cells: 6.8 nCPM
- mucous neck cells: 4.3 nCPM
- mast cells: 1.2 nCPM
Immune cell
- memory B-cell: 169 nTPM
- naive B-cell: 78 nTPM
- total PBMC: 12 nTPM
- plasmacytoid DC: 3.3 nTPM
- myeloid DC: 1.4 nTPM
- basophil: 0.6 nTPM
Brain region
- spinal cord: 3.7 nTPM
- cerebral cortex: 2.2 nTPM
- choroid plexus: 1.5 nTPM
- hypothalamus: 1.2 nTPM
- medulla oblongata: 0.7 nTPM
- basal ganglia: 0.6 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV4-59 as an antibody target. Whether an autoantibody or antibody against IGHV4-59 could matter depends on whether native IGHV4-59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV4-59 is annotated at the cell surface, where native IGHV4-59 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV4-59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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