IGHV4-4
Immunoglobulin heavy variable 4-4
Also known as: HV404_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6R2
- Gene
- IGHV4-4
- Ensembl
- ENSG00000276775
- Chromosome
- 14
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
No narrative summary is available for IGHV4-4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>A0A075B6R2|IGHV4-4
1 MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSGTLSLT CAVSGGSISS SNWWSWVRQP
61 PGKGLEWIGE IYHSGSTNYN PSLKSRVTIS VDKSKNQFSL KLSSVTAADT AVYYCARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV4-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 722 nTPM
Expression across tissuesHPA
Tissue
- urinary bladder: 722 nTPM
- tonsil: 530 nTPM
- colon: 192 nTPM
- spleen: 176 nTPM
- stomach: 165 nTPM
- lymph node: 161 nTPM
Single-cell type
- plasma cells: 32 nCPM
- parietal cells: 1.8 nCPM
- foveolar cells: 0.6 nCPM
- salivary myoepithelial cells: 0.3 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- memory B-cell: 57 nTPM
- naive B-cell: 31 nTPM
- total PBMC: 4.1 nTPM
- plasmacytoid DC: 1.9 nTPM
- naive CD4 T-cell: 0.6 nTPM
- T-reg: 0.6 nTPM
Brain region
- midbrain: 9.4 nTPM
- spinal cord: 0.9 nTPM
- medulla oblongata: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
- hypothalamus: 0.3 nTPM
- pons: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV4-4 as an antibody target. Whether an autoantibody or antibody against IGHV4-4 could matter depends on whether native IGHV4-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV4-4 is annotated at the cell surface, where native IGHV4-4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV4-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...