Seroatlas · Human Serome Atlas

IGHV4-39

Immunoglobulin heavy variable 4-39

Also known as: HV439_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01824
Gene
IGHV4-39
Ensembl
ENSG00000211959
Chromosome
14
Canonical length
125 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

No narrative summary is available for IGHV4-39 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>P01824|IGHV4-39
     1  MDLMCKKMKH LWFFLLLVAA PRWVLSQLQL QESGPGLVKP SETLSLTCTV SGGSISSSSY
    61  YWGWIRQPPG KGLEWIGSIY YSGSTYYNPS LKSRVTISVD TSKNQFSLKL SSVTAADTAV
   121  YYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV4-39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
506 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 506 nTPM
  • spleen: 454 nTPM
  • appendix: 356 nTPM
  • colon: 257 nTPM
  • salivary gland: 244 nTPM
  • small intestine: 136 nTPM

Single-cell type

  • plasma cells: 27 nCPM
  • gastric chief cells: 8.7 nCPM
  • foveolar cells: 3.8 nCPM
  • mucous neck cells: 2.7 nCPM
  • neuroendocrine cells: 1.9 nCPM
  • parietal cells: 1.8 nCPM

Immune cell

  • naive B-cell: 1.7 nTPM
  • memory B-cell: 1.6 nTPM
  • neutrophil: 1.1 nTPM
  • naive CD4 T-cell: 0.5 nTPM
  • basophil: 0.4 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • choroid plexus: 3 nTPM
  • midbrain: 2.2 nTPM
  • medulla oblongata: 1.6 nTPM
  • pons: 1.1 nTPM
  • basal ganglia: 1 nTPM
  • amygdala: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHV4-39.

Disease | ImmuneIEDB

Conditions an epitope on IGHV4-39 was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV4-39 as an antibody target. Whether an autoantibody or antibody against IGHV4-39 could matter depends on whether native IGHV4-39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV4-39 is annotated at the cell surface, where native IGHV4-39 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV4-39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV4-39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...