Seroatlas · Human Serome Atlas

IGHV4-38-2

Immunoglobulin heavy variable 4-38-2

Also known as: ENSG00000275063, HVD82_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DP08
Gene: IGHV4-38-2
Ensembl: ENSG00000275063
Chromosome: Unmapped
Canonical length: 117 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

No narrative summary is available for IGHV4-38-2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0DP08|IGHV4-38-2
     1  MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSETLSLT CTVSGYSISS GYYWGWIRQP
    61  PGKGLEWIGS IYHSGSTYYN PSLKSRVTIS VDTSKNQFSL KLSSVTAADT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV4-38-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 716 nTPM

Expression across tissuesHPA

Tissue

tonsil: 716 nTPM
colon: 584 nTPM
duodenum: 436 nTPM
urinary bladder: 407 nTPM
appendix: 313 nTPM
stomach: 228 nTPM

Single-cell type

plasma cells: 31 nCPM
thymocytes: 3.4 nCPM
foveolar cells: 0.6 nCPM
b-cells: 0.3 nCPM
respiratory ciliated cells: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

memory B-cell: 404 nTPM
naive B-cell: 260 nTPM
total PBMC: 35 nTPM
plasmacytoid DC: 0.9 nTPM
neutrophil: 0.6 nTPM
MAIT T-cell: 0.5 nTPM

Brain region

cerebral cortex: 2.2 nTPM
choroid plexus: 1.5 nTPM
amygdala: 0.7 nTPM
white matter: 0.7 nTPM
medulla oblongata: 0.5 nTPM
hypothalamus: 0.3 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV4-38-2 as an antibody target. Whether an autoantibody or antibody against IGHV4-38-2 could matter depends on whether native IGHV4-38-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV4-38-2 is annotated at the cell surface, where native IGHV4-38-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV4-38-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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