Seroatlas · Human Serome Atlas

IGHV4-34

Immunoglobulin heavy variable 4-34

Also known as: HV434_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P06331
Gene: IGHV4-34
Ensembl: ENSG00000211956
Chromosome: 14
Canonical length: 123 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>P06331|IGHV4-34
     1  MDLLHKNMKH LWFFLLLVAA PRWVLSQVQL QQWGAGLLKP SETLSLTCAV YGGSFSGYYW
    61  SWIRQPPGKG LEWIGEINHS GSTNYNPSLK SRVTISVDTS KNQFSLKLSS VTAADTAVYY
   121  CAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV4-34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 265 nTPM

Expression across tissuesHPA

Tissue

spleen: 265 nTPM
urinary bladder: 253 nTPM
colon: 86 nTPM
salivary gland: 81 nTPM
small intestine: 51 nTPM
stomach: 45 nTPM

Single-cell type

plasma cells: 8.1 nCPM
gastric chief cells: 7.6 nCPM
platelets: 2.8 nCPM
mucous neck cells: 2.4 nCPM
foveolar cells: 0.9 nCPM
b-cells: 0.4 nCPM

Immune cell

neutrophil: 1.1 nTPM
total PBMC: 0.9 nTPM
plasmacytoid DC: 0.5 nTPM
myeloid DC: 0.4 nTPM
classical monocyte: 0.2 nTPM
eosinophil: 0.2 nTPM

Brain region

white matter: 2.5 nTPM
medulla oblongata: 1.2 nTPM
cerebral cortex: 0.9 nTPM
pons: 0.6 nTPM
basal ganglia: 0.5 nTPM
hypothalamus: 0.5 nTPM

OntologyGO

Biological processes

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV4-34 as an antibody target. Whether an autoantibody or antibody against IGHV4-34 could matter depends on whether native IGHV4-34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV4-34 is annotated at the cell surface, where native IGHV4-34 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV4-34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...