Seroatlas · Human Serome Atlas

IGHV4-31

Immunoglobulin heavy variable 4-31

Also known as: HV431_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DP07
Gene: IGHV4-31
Canonical length: 118 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGHV4-31 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>P0DP07|IGHV4-31
     1  MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSQTLSLT CTVSGGSISS GGYYWSWIRQ
    61  HPGKGLEWIG YIYYSGSTYY NPSLKSLVTI SVDTSKNQFS LKLSSVTAAD TAVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV4-31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 436 nTPM

Expression across tissuesHPA

Tissue

tonsil: 436 nTPM
urinary bladder: 179 nTPM
spleen: 130 nTPM
gallbladder: 99 nTPM
colon: 97 nTPM
lymph node: 97 nTPM

Single-cell type

plasma cells: 0.7 nCPM
hepatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

memory B-cell: 44 nTPM
naive B-cell: 19 nTPM
total PBMC: 1.5 nTPM
plasmacytoid DC: 0.6 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

spinal cord: 2.8 nTPM
hypothalamus: 1.3 nTPM
cerebral cortex: 0.7 nTPM
medulla oblongata: 0.5 nTPM
midbrain: 0.4 nTPM
thalamus: 0.3 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV4-31 as an antibody target. Whether an autoantibody or antibody against IGHV4-31 could matter depends on whether native IGHV4-31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV4-31 is annotated at the cell surface, where native IGHV4-31 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV4-31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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