Seroatlas · Human Serome Atlas

IGHV4-28

Immunoglobulin heavy variable 4-28

Also known as: HV428_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0C4DH34
Gene
IGHV4-28
Ensembl
ENSG00000211952
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0C4DH34|IGHV4-28
     1  MKHLWFFLLL VAAPRWVLSQ VQLQESGPGL VKPSDTLSLT CAVSGYSISS SNWWGWIRQP
    61  PGKGLEWIGY IYYSGSTYYN PSLKSRVTMS VDTSKNQFSL KLSSVTAVDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV4-28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 115 nTPM
  • tonsil: 82 nTPM
  • duodenum: 42 nTPM
  • colon: 42 nTPM
  • rectum: 41 nTPM
  • spleen: 41 nTPM

Single-cell type

  • plasma cells: 0.3 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • memory B-cell: 29 nTPM
  • naive B-cell: 13 nTPM
  • total PBMC: 1.9 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • spinal cord: 2.5 nTPM
  • white matter: 0.4 nTPM
  • choroid plexus: 0.2 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV4-28 as an antibody target. Whether an autoantibody or antibody against IGHV4-28 could matter depends on whether native IGHV4-28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV4-28 is annotated at the cell surface, where native IGHV4-28 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV4-28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV4-28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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