Seroatlas · Human Serome Atlas

IGHV3-74

Immunoglobulin heavy variable 3-74

Also known as: HV374_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0B4J1X5
Gene
IGHV3-74
Ensembl
ENSG00000224650
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0B4J1X5|IGHV3-74
     1  MEFGLSWVFL VAILKGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS YWMHWVRQAP
    61  GKGLVWVSRI NSDGSSTSYA DSVKGRFTIS RDNAKNTLYL QMNSLRAEDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV3-74 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
291 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 291 nTPM
  • colon: 103 nTPM
  • salivary gland: 100 nTPM
  • esophagus: 82 nTPM
  • small intestine: 70 nTPM
  • urinary bladder: 44 nTPM

Single-cell type

  • plasma cells: 20 nCPM
  • gastric chief cells: 1.1 nCPM
  • b-cells: 0.4 nCPM
  • mucous neck cells: 0.4 nCPM
  • mast cells: 0.3 nCPM
  • papillary tip epithelial cells: 0.2 nCPM

Immune cell

  • naive CD8 T-cell: 1.2 nTPM
  • neutrophil: 0.9 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM

Brain region

  • cerebral cortex: 1.2 nTPM
  • medulla oblongata: 1.2 nTPM
  • hypothalamus: 0.6 nTPM
  • basal ganglia: 0.5 nTPM
  • spinal cord: 0.5 nTPM
  • pons: 0.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV3-74 as an antibody target. Whether an autoantibody or antibody against IGHV3-74 could matter depends on whether native IGHV3-74 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV3-74 is annotated at the cell surface, where native IGHV3-74 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV3-74 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV3-74. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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