Seroatlas · Human Serome Atlas

IGHV3-7

Immunoglobulin heavy variable 3-7

Also known as: HV307_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01780
Gene
IGHV3-7
Ensembl
ENSG00000211938
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P01780|IGHV3-7
     1  MELGLSWVFL VAILEGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS YWMSWVRQAP
    61  GKGLEWVANI KQDGSEKYYV DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV3-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
899 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 899 nTPM
  • spleen: 577 nTPM
  • colon: 433 nTPM
  • rectum: 284 nTPM
  • salivary gland: 256 nTPM
  • stomach: 216 nTPM

Single-cell type

  • plasma cells: 102 nCPM
  • gastric chief cells: 5.5 nCPM
  • b-cells: 0.6 nCPM
  • salivary myoepithelial cells: 0.6 nCPM
  • innate lymphoid cells: 0.4 nCPM
  • neutrophil progenitors: 0.2 nCPM

Immune cell

  • memory B-cell: 137 nTPM
  • naive B-cell: 108 nTPM
  • total PBMC: 13 nTPM
  • classical monocyte: 0.8 nTPM
  • plasmacytoid DC: 0.6 nTPM
  • basophil: 0.4 nTPM

Brain region

  • spinal cord: 6.5 nTPM
  • midbrain: 4.8 nTPM
  • medulla oblongata: 4 nTPM
  • white matter: 2 nTPM
  • basal ganglia: 1.5 nTPM
  • cerebral cortex: 1.1 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV3-7 as an antibody target. Whether an autoantibody or antibody against IGHV3-7 could matter depends on whether native IGHV3-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV3-7 is annotated at the cell surface, where native IGHV3-7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV3-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV3-7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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