Seroatlas · Human Serome Atlas

IGHV3-66

Immunoglobulin heavy variable 3-66

Also known as: HV366_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0C4DH42
Gene: IGHV3-66
Ensembl: ENSG00000211972
Chromosome: 14
Canonical length: 116 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

116 residues, UniProt reviewed canonical sequence.

>A0A0C4DH42|IGHV3-66
     1  MEFGLSWVFL VAILKGVQCE VQLVESGGGL IQPGGSLRLS CAASGFTVSS NYMSWVRQAP
    61  GKGLEWVSVI YSCGSTYYAD SVKGRFTISR DNSKNTLYLQ MNSLRAEDTA VYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV3-66 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 98 nTPM
colon: 54 nTPM
gallbladder: 44 nTPM
lymph node: 39 nTPM
tonsil: 37 nTPM
rectum: 30 nTPM

Single-cell type

plasma cells: 13 nCPM
thymocytes: 0.8 nCPM
lymphatic endothelial cells: 0.1 nCPM
vascular endothelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

memory B-cell: 39 nTPM
total PBMC: 0.9 nTPM
MAIT T-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
naive B-cell: 0.1 nTPM

Brain region

choroid plexus: 0.6 nTPM
medulla oblongata: 0.4 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV3-66 as an antibody target. Whether an autoantibody or antibody against IGHV3-66 could matter depends on whether native IGHV3-66 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV3-66 is annotated at the cell surface, where native IGHV3-66 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV3-66 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...