Seroatlas · Human Serome Atlas

IGHV3-64D

Immunoglobulin heavy variable 3-64D

Also known as: HV64D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0J9YX35
Gene
IGHV3-64D
Ensembl
ENSG00000282639
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0J9YX35|IGHV3-64D
     1  MEFWLSWVLL VAILKDVQCE VQLVESGGGL VQPGGSLRLS CSASGFTFSS YAMHWVRQAP
    61  GKGLEYVSAI SSNGGSTYYA DSVKGRFTIS RDNSKNTLYL QMSSLRAEDT AVYYCVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV3-64D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
253 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 253 nTPM
  • rectum: 136 nTPM
  • appendix: 132 nTPM
  • colon: 122 nTPM
  • breast: 78 nTPM
  • stomach: 70 nTPM

Single-cell type

  • plasma cells: 2 nCPM
  • parietal cells: 1.8 nCPM
  • erythrocyte progenitors: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • memory B-cell: 43 nTPM
  • naive B-cell: 19 nTPM
  • total PBMC: 4.7 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.9 nTPM
  • hippocampal formation: 0.9 nTPM
  • white matter: 0.8 nTPM
  • choroid plexus: 0.5 nTPM
  • amygdala: 0.3 nTPM
  • basal ganglia: 0.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV3-64D as an antibody target. Whether an autoantibody or antibody against IGHV3-64D could matter depends on whether native IGHV3-64D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV3-64D is annotated at the cell surface, where native IGHV3-64D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV3-64D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV3-64D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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