Seroatlas · Human Serome Atlas

IGHV3-38-3

Probable non-functional immunoglobulin heavy variable 3-38-3

Also known as: HV383_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTE1
Gene: IGHV3-38-3
Canonical length: 115 aa

OverviewNCBI Gene

No narrative summary is available for IGHV3-38-3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P0DTE1|IGHV3-38-3
     1  MQFVLSWVFL VAILKGVQCE VQLVESRGVL VQPGGSLRLS CAASGFTVSS NEMSWVRQAP
    61  GKGLEWVSSI SGGSTYYADS RKGRFTISRD NSKNTLHLQM NSLRAEDTAV YYCKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV3-38-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV3-38-3 as an antibody target. Whether an autoantibody or antibody against IGHV3-38-3 could matter depends on whether native IGHV3-38-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV3-38-3 is annotated at the cell surface, where native IGHV3-38-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV3-38-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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