IGHV3-30
Immunoglobulin heavy variable 3-30
Also known as: HV330_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01768
- Gene
- IGHV3-30
- Ensembl
- ENSG00000270550
- Chromosome
- 14
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01768|IGHV3-30
1 MEFGLSWVFL VALLRGVQCQ VQLVESGGGV VQPGRSLRLS CAASGFTFSS YGMHWVRQAP
61 GKGLEWVAVI SYDGSNKYYA DSVKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCAKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV3-30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 1,209 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 1,209 nTPM
- spleen: 747 nTPM
- stomach: 538 nTPM
- colon: 500 nTPM
- salivary gland: 439 nTPM
- urinary bladder: 356 nTPM
Single-cell type
- plasma cells: 11 nCPM
- gastric chief cells: 2.2 nCPM
- foveolar cells: 0.6 nCPM
- mast cells: 0.6 nCPM
- pericytes: 0.3 nCPM
- b-cells: 0.1 nCPM
Immune cell
- memory B-cell: 165 nTPM
- naive B-cell: 137 nTPM
- total PBMC: 24 nTPM
- naive CD4 T-cell: 0.3 nTPM
- neutrophil: 0.3 nTPM
- basophil: 0.2 nTPM
Brain region
- medulla oblongata: 1.2 nTPM
- choroid plexus: 1.1 nTPM
- cerebral cortex: 0.8 nTPM
- hippocampal formation: 0.7 nTPM
- white matter: 0.5 nTPM
- hypothalamus: 0.4 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV3-30 as an antibody target. Whether an autoantibody or antibody against IGHV3-30 could matter depends on whether native IGHV3-30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV3-30 is annotated at the cell surface, where native IGHV3-30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV3-30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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