IGHV3-23
Immunoglobulin heavy variable 3-23
Also known as: HV323_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01764
- Gene
- IGHV3-23
- Ensembl
- ENSG00000211949
- Chromosome
- 14
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
IGHV3-23 belongs to a cluster of approximately 40 functional variable (V) genes in the immunoglobulin (Ig) heavy chain locus on chromosome 14. For background information on the Ig heavy chain and the V gene cluster, see (MIM 147070).[supplied by OMIM, Apr 2008]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01764|IGHV3-23
1 MEFGLSWLFL VAILKGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS YAMSWVRQAP
61 GKGLEWVSAI SGSGGSTYYA DSVKGRFTIS RDNSKNTLYL QMNSLRAEDT AVYYCAKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV3-23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 2,792 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 2,792 nTPM
- colon: 1,574 nTPM
- duodenum: 1,541 nTPM
- rectum: 1,016 nTPM
- stomach: 996 nTPM
- urinary bladder: 933 nTPM
Single-cell type
- plasma cells: 105 nCPM
- gastric chief cells: 2.2 nCPM
- foveolar cells: 1.8 nCPM
- b-cells: 0.8 nCPM
- neuroendocrine cells: 0.5 nCPM
- salivary ionocytes: 0.4 nCPM
Immune cell
- memory B-cell: 551 nTPM
- naive B-cell: 338 nTPM
- total PBMC: 63 nTPM
- neutrophil: 1 nTPM
- T-reg: 0.8 nTPM
- basophil: 0.4 nTPM
Brain region
- cerebral cortex: 3.8 nTPM
- choroid plexus: 2.8 nTPM
- white matter: 2.2 nTPM
- medulla oblongata: 1.3 nTPM
- spinal cord: 1.2 nTPM
- amygdala: 0.7 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV3-23 as an antibody target. Whether an autoantibody or antibody against IGHV3-23 could matter depends on whether native IGHV3-23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV3-23 is annotated at the cell surface, where native IGHV3-23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV3-23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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