IGHV3-11
Immunoglobulin heavy variable 3-11
Also known as: HV311_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01762
- Gene
- IGHV3-11
- Ensembl
- ENSG00000211941
- Chromosome
- 14
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
No narrative summary is available for IGHV3-11 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01762|IGHV3-11
1 MEFGLSWVFL VAIIKGVQCQ VQLVESGGGL VKPGGSLRLS CAASGFTFSD YYMSWIRQAP
61 GKGLEWVSYI SSSSSYTNYA DSVKGRFTIS RDNAKNSLYL QMNSLRAEDT AVYYCARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV3-11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 573 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 573 nTPM
- colon: 206 nTPM
- spleen: 205 nTPM
- stomach: 194 nTPM
- duodenum: 182 nTPM
- appendix: 165 nTPM
Single-cell type
- plasma cells: 12 nCPM
- gastric chief cells: 3.3 nCPM
- mucous neck cells: 0.8 nCPM
- foveolar cells: 0.6 nCPM
- nk-cells: 0.3 nCPM
- b-cells: 0.1 nCPM
Immune cell
- naive B-cell: 46 nTPM
- memory B-cell: 43 nTPM
- total PBMC: 8.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- medulla oblongata: 1.3 nTPM
- thalamus: 0.6 nTPM
- cerebral cortex: 0.5 nTPM
- choroid plexus: 0.4 nTPM
- white matter: 0.4 nTPM
- pons: 0.2 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV3-11 as an antibody target. Whether an autoantibody or antibody against IGHV3-11 could matter depends on whether native IGHV3-11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV3-11 is annotated at the cell surface, where native IGHV3-11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV3-11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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