IGHV2-70
Immunoglobulin heavy variable 2-70
Also known as: HV270_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01814
- Gene
- IGHV2-70
- Ensembl
- ENSG00000274576
- Chromosome
- 14
- Canonical length
- 119 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>P01814|IGHV2-70
1 MDILCSTLLL LTVPSWVLSQ VTLRESGPAL VKPTQTLTLT CTFSGFSLST SGMCVSWIRQ
61 PPGKALEWLA LIDWDDDKYY STSLKTRLTI SKDTSKNQVV LTMTNMDPVD TATYYCARILocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV2-70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 679 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 679 nTPM
- stomach: 472 nTPM
- spleen: 143 nTPM
- appendix: 91 nTPM
- salivary gland: 89 nTPM
- colon: 81 nTPM
Single-cell type
- plasma cells: 2.9 nCPM
- mucous neck cells: 0.8 nCPM
- basal prostatic cells: 0.3 nCPM
- erythrocytes: 0.2 nCPM
- neutrophils: 0.2 nCPM
- b-cells: 0.1 nCPM
Immune cell
- memory B-cell: 25 nTPM
- naive B-cell: 24 nTPM
- total PBMC: 1.9 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 8.4 nTPM
- spinal cord: 3.8 nTPM
- hypothalamus: 2.4 nTPM
- midbrain: 1.9 nTPM
- white matter: 0.4 nTPM
- medulla oblongata: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV2-70 as an antibody target. Whether an autoantibody or antibody against IGHV2-70 could matter depends on whether native IGHV2-70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV2-70 is annotated at the cell surface, where native IGHV2-70 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV2-70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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