Seroatlas · Human Serome Atlas

IGHV2-5

Immunoglobulin heavy variable 2-5

Also known as: HV205_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01817
Gene: IGHV2-5
Ensembl: ENSG00000211937
Chromosome: 14
Canonical length: 119 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>P01817|IGHV2-5
     1  MDTLCSTLLL LTIPSWVLSQ ITLKESGPTL VKPTQTLTLT CTFSGFSLST SGVGVGWIRQ
    61  PPGKALEWLA LIYWDDDKRY SPSLKSRLTI TKDTSKNQVV LTMTNMDPVD TATYYCAHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV2-5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 1,331 nTPM

Expression across tissuesHPA

Tissue

tonsil: 1,331 nTPM
stomach: 665 nTPM
colon: 435 nTPM
spleen: 333 nTPM
rectum: 277 nTPM
duodenum: 250 nTPM

Single-cell type

plasma cells: 15 nCPM
parietal cells: 8.8 nCPM
gastric chief cells: 6.6 nCPM
mucous neck cells: 2.8 nCPM
foveolar cells: 1.4 nCPM
conjunctival goblet cells: 1 nCPM

Immune cell

naive B-cell: 68 nTPM
memory B-cell: 67 nTPM
total PBMC: 11 nTPM
neutrophil: 3 nTPM
MAIT T-cell: 0.3 nTPM
myeloid DC: 0.1 nTPM

Brain region

pons: 1.3 nTPM
cerebral cortex: 1.1 nTPM
medulla oblongata: 1 nTPM
white matter: 0.7 nTPM
spinal cord: 0.5 nTPM
basal ganglia: 0.4 nTPM

OntologyGO

Biological processes

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV2-5 as an antibody target. Whether an autoantibody or antibody against IGHV2-5 could matter depends on whether native IGHV2-5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV2-5 is annotated at the cell surface, where native IGHV2-5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV2-5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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