Seroatlas · Human Serome Atlas

IGHV1-69D

Immunoglobulin heavy variable 1-69D

Also known as: HV69D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0B4J2H0
Gene
IGHV1-69D
Ensembl
ENSG00000280411
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0B4J2H0|IGHV1-69D
     1  MDWTWRFLFV VAAATGVQSQ VQLVQSGAEV KKPGSSVKVS CKASGGTFSS YAISWVRQAP
    61  GQGLEWMGGI IPIFGTANYA QKFQGRVTIT ADESTSTAYM ELSSLRSEDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV1-69D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
2,700 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 2,700 nTPM
  • tonsil: 2,073 nTPM
  • stomach: 930 nTPM
  • colon: 586 nTPM
  • duodenum: 462 nTPM
  • appendix: 436 nTPM

Single-cell type

  • plasma cells: 25 nCPM
  • platelets: 2.8 nCPM
  • gastric chief cells: 1.1 nCPM
  • mast cells: 0.9 nCPM
  • monocytes: 0.4 nCPM
  • mucous neck cells: 0.4 nCPM

Immune cell

  • naive B-cell: 435 nTPM
  • memory B-cell: 185 nTPM
  • total PBMC: 34 nTPM
  • plasmacytoid DC: 1.3 nTPM
  • basophil: 0.8 nTPM
  • naive CD4 T-cell: 0.4 nTPM

Brain region

  • medulla oblongata: 2.4 nTPM
  • choroid plexus: 2 nTPM
  • cerebral cortex: 1.4 nTPM
  • white matter: 1 nTPM
  • spinal cord: 0.5 nTPM
  • basal ganglia: 0.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV1-69D as an antibody target. Whether an autoantibody or antibody against IGHV1-69D could matter depends on whether native IGHV1-69D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV1-69D is annotated at the cell surface, where native IGHV1-69D is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV1-69D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV1-69D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...