IGHV1-46
Immunoglobulin heavy variable 1-46
Also known as: HV146_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01743
- Gene
- IGHV1-46
- Ensembl
- ENSG00000211962
- Chromosome
- 14
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P01743|IGHV1-46
1 MDWTWRVFCL LAVAPGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTS YYMHWVRQAP
61 GQGLEWMGII NPSGGSTSYA QKFQGRVTMT RDTSTSTVYM ELSSLRSEDT AVYYCARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHV1-46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 118 nTPM
Expression across tissuesHPA
Tissue
- spleen: 118 nTPM
- colon: 70 nTPM
- salivary gland: 66 nTPM
- rectum: 42 nTPM
- small intestine: 33 nTPM
- stomach: 24 nTPM
Single-cell type
- plasma cells: 11 nCPM
- gastric chief cells: 4.4 nCPM
- mucous neck cells: 1.6 nCPM
- foveolar cells: 0.7 nCPM
- mast cells: 0.6 nCPM
- neuroendocrine cells: 0.5 nCPM
Immune cell
- naive B-cell: 0.3 nTPM
- total PBMC: 0.3 nTPM
- plasmacytoid DC: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- pons: 0.3 nTPM
- amygdala: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- choroid plexus: 0.1 nTPM
- thalamus: 0.1 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHV1-46 as an antibody target. Whether an autoantibody or antibody against IGHV1-46 could matter depends on whether native IGHV1-46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHV1-46 is annotated at the cell surface, where native IGHV1-46 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHV1-46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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