Seroatlas · Human Serome Atlas

IGHV1-38-4

Probable non-functional immunoglobulin heavy variable 1-38-4

Also known as: HV384_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTW3
Gene: IGHV1-38-4
Canonical length: 117 aa

OverviewNCBI Gene

No narrative summary is available for IGHV1-38-4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P0DTW3|IGHV1-38-4
     1  MDWNWRILFL VVATTGAHSQ VQLVQSWAEV RKSGASVKVS CSFSGFTITS YGIHWVQQSP
    61  GQGLEWMGWI NPGNGSPSYA KKFQGRFTMT RDMSTTTAYT DLSSLTSEDM AVYYYAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV1-38-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV1-38-4 as an antibody target. Whether an autoantibody or antibody against IGHV1-38-4 could matter depends on whether native IGHV1-38-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV1-38-4 is annotated at the cell surface, where native IGHV1-38-4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV1-38-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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