Seroatlas · Human Serome Atlas

IGHV1-3

Immunoglobulin heavy variable 1-3

Also known as: HV103_HUMAN, VI-3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0C4DH29
Gene: IGHV1-3
Ensembl: ENSG00000211935
Chromosome: 14
Canonical length: 117 aa
Protein class: Immunoglobulin genes, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0C4DH29|IGHV1-3
     1  MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTS YAMHWVRQAP
    61  GQRLEWMGWI NAGNGNTKYS QKFQGRVTIT RDTSASTAYM ELSSLRSEDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV1-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 586 nTPM

Expression across tissuesHPA

Tissue

tonsil: 586 nTPM
spleen: 230 nTPM
rectum: 209 nTPM
duodenum: 205 nTPM
appendix: 196 nTPM
colon: 180 nTPM

Single-cell type

plasma cells: 5.4 nCPM
platelets: 2.8 nCPM
foveolar cells: 0.9 nCPM
mucous neck cells: 0.8 nCPM
b-cells: 0.4 nCPM
mast cells: 0.3 nCPM

Immune cell

memory B-cell: 53 nTPM
naive B-cell: 28 nTPM
total PBMC: 6.1 nTPM
plasmacytoid DC: 5.8 nTPM
T-reg: 1.7 nTPM
naive CD4 T-cell: 1.6 nTPM

Brain region

cerebral cortex: 1 nTPM
choroid plexus: 0.5 nTPM
medulla oblongata: 0.5 nTPM
thalamus: 0.3 nTPM
hypothalamus: 0.2 nTPM
pons: 0.2 nTPM

OntologyGO

Biological processes

immunoglobulin mediated immune response

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV1-3 as an antibody target. Whether an autoantibody or antibody against IGHV1-3 could matter depends on whether native IGHV1-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV1-3 is annotated at the cell surface, where native IGHV1-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV1-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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