Seroatlas · Human Serome Atlas

IGHV1-2

Immunoglobulin heavy variable 1-2

Also known as: HV102_HUMAN, V35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23083
Gene
IGHV1-2
Ensembl
ENSG00000211934
Chromosome
14
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P23083|IGHV1-2
     1  MDWTWRILFL VAAATGAHSQ VQLVQSGAEV KKPGASVKVS CKASGYTFTG YYMHWVRQAP
    61  GQGLEWMGWI NPNSGGTNYA QKFQGWVTMT RDTSISTAYM ELSRLRSDDT AVYYCAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHV1-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,082 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,082 nTPM
  • colon: 432 nTPM
  • lymph node: 379 nTPM
  • spleen: 371 nTPM
  • appendix: 343 nTPM
  • rectum: 265 nTPM

Single-cell type

  • plasma cells: 17 nCPM
  • platelets: 2.8 nCPM
  • gastric progenitor cells: 1.3 nCPM
  • foveolar cells: 0.9 nCPM
  • mucous neck cells: 0.8 nCPM
  • vascular smooth muscle cells: 0.2 nCPM

Immune cell

  • naive B-cell: 348 nTPM
  • memory B-cell: 287 nTPM
  • total PBMC: 34 nTPM
  • neutrophil: 6.2 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • naive CD4 T-cell: 1.5 nTPM

Brain region

  • cerebral cortex: 2.3 nTPM
  • white matter: 1.1 nTPM
  • choroid plexus: 0.9 nTPM
  • medulla oblongata: 0.8 nTPM
  • amygdala: 0.5 nTPM
  • pons: 0.5 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHV1-2 as an antibody target. Whether an autoantibody or antibody against IGHV1-2 could matter depends on whether native IGHV1-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHV1-2 is annotated at the cell surface, where native IGHV1-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHV1-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGHV1-2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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