IGHJ1
Immunoglobulin heavy joining 1
Also known as: HJ01_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH62
- Gene
- IGHJ1
- Ensembl
- ENSG00000211905
- Chromosome
- 14
- Canonical length
- 17 aa
- Protein class
- Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
17 residues, UniProt reviewed canonical sequence.
>A0A0C4DH62|IGHJ1
1 AEYFQHWGQG TLVTVSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 393 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 393 nTPM
- duodenum: 344 nTPM
- stomach: 246 nTPM
- colon: 243 nTPM
- appendix: 185 nTPM
- rectum: 165 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory B-cell: 277 nTPM
- naive B-cell: 182 nTPM
- plasmacytoid DC: 99 nTPM
- total PBMC: 29 nTPM
- memory CD8 T-cell: 2.5 nTPM
- classical monocyte: 0.6 nTPM
Brain region
- cerebral cortex: 3.6 nTPM
- medulla oblongata: 2.7 nTPM
- pons: 1 nTPM
- white matter: 0.7 nTPM
- spinal cord: 0.6 nTPM
- thalamus: 0.5 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHJ1 as an antibody target. Whether an autoantibody or antibody against IGHJ1 could matter depends on whether native IGHJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHJ1 is annotated at the cell surface, where native IGHJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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