IGHD1-1
Immunoglobulin heavy diversity 1-1
Also known as: HD101_HUMAN, IGHD11
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0DOY5
- Gene
- IGHD1-1
- Ensembl
- ENSG00000236170
- Chromosome
- 14
- Canonical length
- 5 aa
- Protein class
- Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
5 residues, UniProt reviewed canonical sequence.
>P0DOY5|IGHD1-1
1 GTTGTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHD1-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHD1-1 as an antibody target. Whether an autoantibody or antibody against IGHD1-1 could matter depends on whether native IGHD1-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHD1-1 is annotated at the cell surface, where native IGHD1-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHD1-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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