Seroatlas · Human Serome Atlas

IGFLR1

IGF-like family receptor 1

Also known as: FLJ22573, IGFR1_HUMAN, TMEM149, U2AF1L4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H665
Gene: IGFLR1
Ensembl: ENSG00000126246
Chromosome: 19
Canonical length: 355 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q9H665|IGFLR1
     1  MGPGRCLLTA LLLLALAPPP EASQYCGRLE YWNPDNKCCS SCLQRFGPPP CPDYEFRENC
    61  GLNDHGDFVT PPFRKCSSGQ CNPDGAELCS PCGGGAVTPT PAAGGGRTPW RCRERPVPAK
   121  GHCPLTPGNP GAPSSQERSS PASSIAWRTP EPVPQQAWPN FLPLVVLVLL LTLAVIAILL
   181  FILLWHLCWP KEKADPYPYP GLVCGVPNTH TPSSSHLSSP GALETGDTWK EASLLPLLSR
   241  ELSSLASQPL SRLLDELEVL EELIVLLDPE PGPGGGMAHG TTRHLAARYG LPAAWSTFAY
   301  SLRPSRSPLR ALIEMVVARE PSASLGQLGT HLAQLGRADA LRVLSKLGSS GVCWA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

liver: 47 nTPM
lymph node: 31 nTPM
spleen: 27 nTPM
tonsil: 22 nTPM
appendix: 18 nTPM
kidney: 14 nTPM

Single-cell type

pdcs: 23 nCPM
hepatocytes: 22 nCPM
cdc: 17 nCPM
hofbauer cells: 13 nCPM
tuft cells: 12 nCPM
monocytes: 10 nCPM

Immune cell

plasmacytoid DC: 902 nTPM
myeloid DC: 254 nTPM
neutrophil: 209 nTPM
classical monocyte: 191 nTPM
eosinophil: 185 nTPM
naive B-cell: 173 nTPM

Brain region

hypothalamus: 16 nTPM
medulla oblongata: 15 nTPM
cerebral cortex: 13 nTPM
thalamus: 12 nTPM
pons: 12 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.8
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Death-like domain superfamily
IGF-like family receptor 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGFLR1 as an antibody target. Whether an autoantibody or antibody against IGFLR1 could matter depends on whether native IGFLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGFLR1 is annotated at the cell surface, where native IGFLR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGFLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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