Seroatlas · Human Serome Atlas

IGFL4

Insulin growth factor-like family member 4

Also known as: IGFL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6B9Z1
Gene: IGFL4
Ensembl: ENSG00000204869
Chromosome: 19
Canonical length: 124 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Cytosol
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q6B9Z1|IGFL4
     1  MVPRISAAIF IFELLGSNSE GVTDLRLWLC QPAPRCGEWT YNPLEQCCDD GVILDLNQTR
    61  LCGSSCTFWP CFQHCCLESL GSQNQTVVRF KVPGMKPDCK SSPITRICAQ EYHPKSPVSR
   121  SDLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

retina: 46 nTPM
skin: 12 nTPM
bone marrow: 6.9 nTPM
liver: 6.2 nTPM
epididymis: 5.8 nTPM
skeletal muscle: 4.9 nTPM

Single-cell type

rod photoreceptor cells: 90 nCPM
gonadotrophs: 49 nCPM
cone photoreceptor cells: 35 nCPM
brain inhibitory neurons: 33 nCPM
thyrotrophs: 33 nCPM
retinal bipolar cells: 32 nCPM

Immune cell

basophil: 2.5 nTPM
neutrophil: 1.4 nTPM
naive B-cell: 1 nTPM
plasmacytoid DC: 0.9 nTPM
eosinophil: 0.8 nTPM
gdT-cell: 0.5 nTPM

Brain region

white matter: 228 nTPM
cerebral cortex: 224 nTPM
cerebellum: 210 nTPM
basal ganglia: 184 nTPM
hippocampal formation: 176 nTPM
choroid plexus: 173 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

signaling receptor binding

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGFL4 as an antibody target. Whether an autoantibody or antibody against IGFL4 could matter depends on whether native IGFL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGFL4 is annotated as secreted, so native IGFL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IGFL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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