IGFL3
Insulin growth factor-like family member 3
Also known as: IGFL3_HUMAN, UNQ483
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UXB1
- Gene
- IGFL3
- Ensembl
- ENSG00000188624
- Chromosome
- 19
- Canonical length
- 125 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
125 residues, UniProt reviewed canonical sequence.
>Q6UXB1|IGFL3
1 MRPRCCILAL VCWITVFLLQ CSKGTTDAPV GSGLWLCQPT PRCGNKIYNP SEQCCYDDAI
61 LSLKETRRCG STCTFWPCFE LCCPESFGPQ QKFLVKLRVL GMKSQCHLSP ISRSCTRNRR
121 HVLYPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGFL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 26 nTPM
Expression across tissuesHPA
Tissue
- skin: 26 nTPM
- breast: 1.4 nTPM
- parathyroid gland: 0.5 nTPM
- retina: 0.4 nTPM
- epididymis: 0.3 nTPM
- skeletal muscle: 0.3 nTPM
Single-cell type
- suprabasal keratinocytes: 6.3 nCPM
- medullary thymic epithelial cells: 4.8 nCPM
- cone photoreceptor cells: 2.1 nCPM
- kupffer cells: 2 nCPM
- basal keratinocytes: 1.5 nCPM
- late spermatids: 1.1 nCPM
Immune cell
- naive B-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 13 nTPM
- basal ganglia: 11 nTPM
- cerebral cortex: 11 nTPM
- pons: 11 nTPM
- medulla oblongata: 10 nTPM
- amygdala: 9.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.18
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.15
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGFL3 as an antibody target. Whether an autoantibody or antibody against IGFL3 could matter depends on whether native IGFL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGFL3 is annotated as secreted, so native IGFL3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IGFL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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