IGFL2
Insulin growth factor-like family member 2
Also known as: IGFL2_HUMAN, UNQ645
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWQ7
- Gene
- IGFL2
- Ensembl
- ENSG00000204866
- Chromosome
- 19
- Canonical length
- 119 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>Q6UWQ7|IGFL2
1 MVPRIFAPAY VSVCLLLLCP REVIAPAGSE PWLCQPAPRC GDKIYNPLEQ CCYNDAIVSL
61 SETRQCGPPC TFWPCFELCC LDSFGLTNDF VVKLKVQGVN SQCHSSPISS KCESRRRFPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGFL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 40 nTPM
Expression across tissuesHPA
Tissue
- skin: 40 nTPM
- testis: 3.8 nTPM
- adipose tissue: 2.3 nTPM
- breast: 1.9 nTPM
- lymph node: 1.9 nTPM
- esophagus: 1.5 nTPM
Single-cell type
- suprabasal keratinocytes: 9.2 nCPM
- early primary spermatocytes: 7.2 nCPM
- late primary spermatocytes: 7.1 nCPM
- differentiating spermatogonia: 6.8 nCPM
- late spermatids: 6.8 nCPM
- early spermatids: 6.2 nCPM
Immune cell
- memory CD4 T-cell: 0.3 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 4 nTPM
- pons: 2.6 nTPM
- cerebral cortex: 2.4 nTPM
- medulla oblongata: 2.4 nTPM
- hypothalamus: 2.2 nTPM
- amygdala: 1.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.18
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGFL2 as an antibody target. Whether an autoantibody or antibody against IGFL2 could matter depends on whether native IGFL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGFL2 is annotated as secreted, so native IGFL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IGFL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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