IGFL1
Insulin growth factor-like family member 1
Also known as: IGFL1_HUMAN, UNQ644
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UW32
- Gene
- IGFL1
- Ensembl
- ENSG00000188293
- Chromosome
- 19
- Canonical length
- 110 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in other tissues
- Quaternary structure
- Homodimer
OverviewNCBI Gene
The protein encoded by this gene is a member of the insulin-like growth factor family of signaling molecules. The encoded protein is synthesized as a precursor protein and is proteolytically cleaved to form a secreted mature peptide. The mature peptide binds to a receptor, which in mouse was found on the cell surface of T cells. Increased expression of this gene may be linked to psoriasis. [provided by RefSeq, Aug 2016]
Canonical amino-acid sequenceUniProt
110 residues, UniProt reviewed canonical sequence.
>Q6UW32|IGFL1
1 MAPRGCIVAV FAIFCISRLL CSHGAPVAPM TPYLMLCQPH KRCGDKFYDP LQHCCYDDAV
61 VPLARTQTCG NCTFRVCFEQ CCPWTFMVKL INQNCDSART SDDRLCRSVSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGFL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 115 nTPM
- vagina: 33 nTPM
- salivary gland: 30 nTPM
- cervix: 20 nTPM
- tonsil: 4.5 nTPM
- skin: 3.4 nTPM
Single-cell type
- esophageal apical cells: 676 nCPM
- suprabasal keratinocytes: 188 nCPM
- esophageal suprabasal cells: 118 nCPM
- esophageal basal cells: 8.3 nCPM
- urothelial cells: 6.6 nCPM
- myosatellite cells: 4.6 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- midbrain: 0.2 nTPM
- amygdala: 0.1 nTPM
- basal ganglia: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- hypothalamus: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- 0.21
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGFL1 as an antibody target. Whether an autoantibody or antibody against IGFL1 could matter depends on whether native IGFL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGFL1 is annotated as secreted, so native IGFL1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IGFL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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