Seroatlas · Human Serome Atlas

IGDCC3

Immunoglobulin superfamily DCC subclass member 3

Also known as: HsT18880, IGDC3_HUMAN, PUNC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVU1
Gene: IGDCC3
Ensembl: ENSG00000174498
Chromosome: 15
Canonical length: 814 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within neuromuscular process controlling balance. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

814 residues, UniProt reviewed canonical sequence.

>Q8IVU1|IGDCC3
     1  MAVQRAASPR RPPAPLWPRL LLPLLLLLLP APSEGLGHSA ELAFAVEPSD DVAVPGQPIV
    61  LDCRVEGTPP VRITWRKNGV ELPESTHSTL LANGSLMIRH FRLEPGGSPS DEGDYECVAQ
   121  NRFGLVVSRK ARIQAATMSD FHVHPQATVG EEGGVARFQC QIHGLPKPLI TWEKNRVPID
   181  TDNERYTLLP KGVLQITGLR AEDGGIFHCV ASNIASIRIS HGARLTVSGS GSGAYKEPAI
   241  LVGPENLTLT VHQTAVLECV ATGNPRPIVS WSRLDGRPIG VEGIQVLGTG NLIISDVTVQ
   301  HSGVYVCAAN RPGTRVRRTA QGRLVVQAPA EFVQHPQSIS RPAGTTAMFT CQAQGEPPPH
   361  VTWLKNGQVL GPGGHVRLKN NNSTLTISGI GPEDEAIYQC VAENSAGSSQ ASARLTVLWA
   421  EGLPGPPRNV RAVSVSSTEV RVSWSEPLAN TKEIIGYVLH IRKAADPPEL EYQEAVSKST
   481  FQHLVSDLEP STAYSFYIKA YTPRGASSAS VPTLASTLGE APAPPPLSVR VLGSSSLQLL
   541  WEPWPRLAQH EGGFKLFYRP ASKTSFTGPI LLPGTVSSYN LSQLDPTAVY EVKLLAYNQH
   601  GDGNATVRFV SLRGASERTA LSPPCDCRKE EAANQTSTTG IVIGIHIGVT CIIFCVLFLL
   661  FGQRGRVLLC KDVENQLSPP QGPRSQRDPG ILALNGARRG QRGQLGRDEK RVDMKELEQL
   721  FPPASAAGQP DPRPTQDPAA PAPCEETQLS VLPLQGCGLM EGKTTEAKTT EATAPCAGLA
   781  AAPPPPDGGP GLLSEGQASR PAAARVTQPA HSEQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGDCC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 6.3 nTPM
placenta: 5.7 nTPM
parathyroid gland: 4.8 nTPM
testis: 2.7 nTPM
cerebral cortex: 2.3 nTPM
amygdala: 2.1 nTPM

Single-cell type

cytotrophoblasts: 156 nCPM
late spermatids: 139 nCPM
early spermatids: 51 nCPM
syncytiotrophoblasts: 41 nCPM
astrocytes: 40 nCPM
migrating cytotrophoblasts: 39 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 8.1 nTPM
thalamus: 7.9 nTPM
midbrain: 7.1 nTPM
hippocampal formation: 6.7 nTPM
pons: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGDCC3 as an antibody target. Whether an autoantibody or antibody against IGDCC3 could matter depends on whether native IGDCC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGDCC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IGDCC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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