Seroatlas · Human Serome Atlas

IGBP1C

Immunoglobulin-binding protein 1 family member C

Also known as: IGB1C_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1W2PR95
Gene: IGBP1C
Canonical length: 340 aa

OverviewNCBI Gene

No narrative summary is available for IGBP1C in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>A0A1W2PR95|IGBP1C
     1  MAAAEDEFLP PPRLPELFDS SKQLLDEVEG ATEPTGSRIV QEKVFKGLDL LDKVAKMLSQ
    61  LDLFSRNEDL EEITSTDLKY LMVPAFQGAL TMKQVNPRKR LDHLQQAREH FIKYLTQCHY
   121  YRVAEFELPQ TKTNSAENHG AITSTAYPSL VAMASQRQAK IERYKQKKVL EHKLSTMKSA
   181  VESGQADNER VREYYLLHLQ RWIDISLEEI ESIDQEIKIL GEKDSSREAS TSNSCHQKRP
   241  PMKPFILTRN MAQAKVFGAG YPSLASMTVS DWYDQHQKHG VLPDQGIAKA TPEEFRKATQ
   301  QQEDQEKEEE DDEQTLQRAR EWDDWKDTHP RGYGNRQNMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGBP1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43

OntologyGO

Biological processes

Molecular functions

protein phosphatase 2A binding

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGBP1C as an antibody target. Whether an autoantibody or antibody against IGBP1C could matter depends on whether native IGBP1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGBP1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IGBP1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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