Seroatlas · Human Serome Atlas

IFRD1

Interferon-related developmental regulator 1

Also known as: IFRD1_HUMAN, PC4, TIS7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00458
Gene
IFRD1
Ensembl
ENSG00000006652
Chromosome
7
Canonical length
451 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is an immediate early gene that encodes a protein related to interferon-gamma. This protein may function as a transcriptional co-activator/repressor that controls the growth and differentiation of specific cell types during embryonic development and tissue regeneration. Mutations in this gene are associated with sensory/motor neuropathy with ataxia. This gene may also be involved in modulating the pathogenesis of cystic fibrosis lung disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>O00458|IFRD1
     1  MPKNKKRNTP HRGSSAGGGG SGAAAATAAT AGGQHRNVQP FSDEDASIET MSHCSGYSDP
    61  SSFAEDGPEV LDEEGTQEDL EYKLKGLIDL TLDKSAKTRQ AALEGIKNAL ASKMLYEFIL
   121  ERRMTLTDSI ERCLKKGKSD EQRAAAALAS VLCIQLGPGI ESEEILKTLG PILKKIICDG
   181  SASMQARQTC ATCFGVCCFI ATDDITELYS TLECLENIFT KSYLKEKDTT VICSTPNTVL
   241  HISSLLAWTL LLTICPINEV KKKLEMHFHK LPSLLSCDDV NMRIAAGESL ALLFELARGI
   301  ESDFFYEDME SLTQMLRALA TDGNKHRAKV DKRKQRSVFR DVLRAVEERD FPTETIKFGP
   361  ERMYIDCWVK KHTYDTFKEV LGSGMQYHLQ SNEFLRNVFE LGPPVMLDAA TLKTMKISRF
   421  ERHLYNSAAF KARTKARSKC RDKRADVGEF F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 54 nTPM
  • pancreas: 48 nTPM
  • choroid plexus: 27 nTPM
  • blood vessel: 18 nTPM
  • skeletal muscle: 18 nTPM
  • stomach: 16 nTPM

Single-cell type

  • early spermatids: 109 nCPM
  • choroid plexus epithelial cells: 100 nCPM
  • microglia: 83 nCPM
  • astrocytes: 82 nCPM
  • renal connecting tubule cells: 77 nCPM
  • loop of henle epithelial cells: 73 nCPM

Immune cell

  • neutrophil: 113 nTPM
  • eosinophil: 64 nTPM
  • basophil: 20 nTPM
  • memory B-cell: 8.8 nTPM
  • T-reg: 8.6 nTPM
  • NK-cell: 8.1 nTPM

Brain region

  • choroid plexus: 76 nTPM
  • hypothalamus: 49 nTPM
  • white matter: 48 nTPM
  • cerebral cortex: 42 nTPM
  • basal ganglia: 38 nTPM
  • hippocampal formation: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFRD1 as an antibody target. Whether an autoantibody or antibody against IFRD1 could matter depends on whether native IFRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFRD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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