Seroatlas · Human Serome Atlas

IFNLR1

Interferon lambda receptor 1

Also known as: CRF2/12, IFNLR, IL-28R1, IL28RA, INLR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IU57
Gene
IFNLR1
Ensembl
ENSG00000185436
Chromosome
1
Canonical length
520 aa
Protein class
Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8IU57|IFNLR1
     1  MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP QDVTYFVAYQ
    61  SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV RTVSPSSKSP WVESEYLDYL
   121  FEVEPAPPVL VLTQTEEILS ANATYQLPPC MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ
   181  PVQITLQPAA SEHHCLSART IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL
   241  VIAAGGVIWK TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR
   301  GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL GQEHQAPGHS
   361  EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR AGSSGYLAEK GPGQGPGGDG
   421  HQESLPPPEF SKDSGFLEEL PEDNLSSWAT WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP
   481  EEEEEARESE IEDSDAGSWG AESTQRTEDR GRTLGHYMAR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNLR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
9.1 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 9.1 nTPM
  • small intestine: 8.7 nTPM
  • liver: 8.1 nTPM
  • lymph node: 7.3 nTPM
  • skin: 6.9 nTPM
  • cerebellum: 6.4 nTPM

Single-cell type

  • ocular epithelial cells: 114 nCPM
  • pdcs: 110 nCPM
  • urothelial cells: 103 nCPM
  • enterocytes: 102 nCPM
  • epididymal efferent duct ciliated cells: 92 nCPM
  • epididymal efferent duct absorptive cells: 73 nCPM

Immune cell

  • plasmacytoid DC: 11 nTPM
  • naive B-cell: 5.9 nTPM
  • memory B-cell: 4.9 nTPM
  • gdT-cell: 1.8 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.4 nTPM

Brain region

  • cerebellum: 14 nTPM
  • hypothalamus: 6.9 nTPM
  • white matter: 6.9 nTPM
  • medulla oblongata: 6.3 nTPM
  • pons: 6.2 nTPM
  • midbrain: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0.06
gnomAD missense Z
0.77
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNLR1 as an antibody target. Whether an autoantibody or antibody against IFNLR1 could matter depends on whether native IFNLR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNLR1 is annotated at the cell surface, where native IFNLR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFNLR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFNLR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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