Seroatlas · Human Serome Atlas

IFNL4

Interferon lambda-4

Also known as: IFNL4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
K9M1U5
Gene
IFNL4
Canonical length
179 aa
Protein class
Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IFNL4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

179 residues, UniProt reviewed canonical sequence.

>K9M1U5|IFNL4
     1  MRPSVWAAVA AGLWVLCTVI AAAPRRCLLS HYRSLEPRTL AAAKALRDRY EEEALSWGQR
    61  NCSFRPRRDP PRPSSCARLR HVARGIADAQ AVLSGLHRSE LLPGAGPILE LLAAAGRDVA
   121  ACLELARPGS SRKVPGAQKR RHKPRRADSP RCRKASVVFN LLRLLTWELR LAAHSGPCL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
0.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 0.1 nTPM
  • testis: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM

Single-cell type

  • early spermatids: 1.4 nCPM
  • thymocytes: 0.8 nCPM
  • hematopoietic stem cells: 0.5 nCPM
  • differentiating spermatogonia: 0.4 nCPM
  • megakaryocyte-erythroid progenitors: 0.4 nCPM
  • undifferentiated spermatogonia: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 1.7 nTPM
  • hypothalamus: 1.5 nTPM
  • midbrain: 1.1 nTPM
  • hippocampal formation: 0.9 nTPM
  • amygdala: 0.7 nTPM
  • cerebral cortex: 0.7 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNL4 as an antibody target. Whether an autoantibody or antibody against IFNL4 could matter depends on whether native IFNL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNL4 is annotated as secreted, so native IFNL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IFNL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IFNL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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