Seroatlas · Human Serome Atlas

IFNGR2

Interferon gamma receptor 2

Also known as: AF-1, IFNGT1, INGR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P38484
Gene: IFNGR2
Ensembl: ENSG00000159128
Chromosome: 21
Canonical length: 337 aa
Protein class: Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>P38484|IFNGR2
     1  MRPTLLWSLL LLLGVFAAAA AAPPDPLSQL PAPQHPKIRL YNAEQVLSWE PVALSNSTRP
    61  VVYQVQFKYT DSKWFTADIM SIGVNCTQIT ATECDFTAAS PSAGFPMDFN VTLRLRAELG
   121  ALHSAWVTMP WFQHYRNVTV GPPENIEVTP GEGSLIIRFS SPFDIADTST AFFCYYVHYW
   181  EKGGIQQVKG PFRSNSISLD NLKPSRVYCL QVQAQLLWNK SNIFRVGHLS NISCYETMAD
   241  ASTELQQVIL ISVGTFSLLS VLAGACFFLV LKYRGLIKYW FHTPPSIPLQ IEEYLKDPTQ
   301  PILEALDKDS SPKDDVWDSV SIISFPEKEQ EDVLQTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNGR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

spleen: 80 nTPM
adipose tissue: 73 nTPM
esophagus: 68 nTPM
breast: 66 nTPM
salivary gland: 65 nTPM
lung: 62 nTPM

Single-cell type

neutrophils: 217 nCPM
microglia: 174 nCPM
monocytes: 94 nCPM
renal collecting duct intercalated cells: 86 nCPM
papillary tip epithelial cells: 82 nCPM
urothelial cells: 81 nCPM

Immune cell

neutrophil: 671 nTPM
non-classical monocyte: 318 nTPM
classical monocyte: 286 nTPM
intermediate monocyte: 282 nTPM
basophil: 226 nTPM
total PBMC: 199 nTPM

Brain region

white matter: 47 nTPM
hypothalamus: 43 nTPM
spinal cord: 39 nTPM
thalamus: 38 nTPM
medulla oblongata: 37 nTPM
cerebral cortex: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IFNGR2.

Disease | AllUniProt

Conditions IFNGR2 is implicated in, by any mechanism.

Immunodeficiency 28 (IMD28) MIM:614889

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 284 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 28

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.95
gnomAD missense Z: 0.83
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFNGR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

JAK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNGR2 as an antibody target. Whether an autoantibody or antibody against IFNGR2 could matter depends on whether native IFNGR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNGR2 is annotated at the cell surface, where native IFNGR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFNGR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...