Seroatlas · Human Serome Atlas

IFI27L2

Interferon alpha-inducible protein 27-like protein 2

Also known as: FAM14A, I27L2_HUMAN, TLH29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2X8
Gene: IFI27L2
Ensembl: ENSG00000119632
Chromosome: 14
Canonical length: 130 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Involved in apoptotic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q9H2X8|IFI27L2
     1  MMKRAAAAAV GGALAVGAVP VVLSAMGFTG AGIAASSIAA KMMSAAAIAN GGGVSAGSLV
    61  ATLQSVGAAG LSTSSNILLA SVGSVLGACL GNSPSSSLPA EPEAKEDEAR ENVPQGEPPK
   121  PPLKSEKHEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFI27L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 220 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 220 nTPM
midbrain: 213 nTPM
amygdala: 212 nTPM
choroid plexus: 183 nTPM
hypothalamus: 179 nTPM
hippocampal formation: 168 nTPM

Single-cell type

megakaryocytes: 513 nCPM
platelets: 395 nCPM
decidual stromal cells: 257 nCPM
melanocytes: 250 nCPM
esophageal suprabasal cells: 164 nCPM
hofbauer cells: 164 nCPM

Immune cell

classical monocyte: 240 nTPM
total PBMC: 218 nTPM
memory B-cell: 215 nTPM
T-reg: 204 nTPM
naive B-cell: 203 nTPM
myeloid DC: 185 nTPM

Brain region

white matter: 101 nTPM
hypothalamus: 100 nTPM
medulla oblongata: 86 nTPM
spinal cord: 82 nTPM
thalamus: 81 nTPM
cerebellum: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFI27L2 as an antibody target. Whether an autoantibody or antibody against IFI27L2 could matter depends on whether native IFI27L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFI27L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFI27L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...