Seroatlas · Human Serome Atlas

IFI27L1

Interferon alpha-inducible protein 27-like protein 1

Also known as: FAM14B, I27L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BM0
Gene: IFI27L1
Ensembl: ENSG00000165948
Chromosome: 14
Canonical length: 104 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable molecular adaptor activity. Involved in apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

104 residues, UniProt reviewed canonical sequence.

>Q96BM0|IFI27L1
     1  MGKESGWDSG RAAVAAVVGG VVAVGTVLVA LSAMGFTSVG IAASSIAAKM MSTAAIANGG
    61  GVAAGSLVAI LQSVGAAGLS VTSKVIGGFA GTALGAWLGS PPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFI27L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

testis: 98 nTPM
choroid plexus: 86 nTPM
adrenal gland: 51 nTPM
ovary: 40 nTPM
amygdala: 29 nTPM
cerebral cortex: 29 nTPM

Single-cell type

early spermatids: 279 nCPM
late primary spermatocytes: 210 nCPM
late spermatids: 176 nCPM
platelets: 169 nCPM
granulosa cells: 158 nCPM
sertoli cells: 83 nCPM

Immune cell

basophil: 16 nTPM
T-reg: 5.4 nTPM
plasmacytoid DC: 4.6 nTPM
memory CD4 T-cell: 4 nTPM
NK-cell: 3.9 nTPM
naive CD8 T-cell: 3.3 nTPM

Brain region

choroid plexus: 19 nTPM
hypothalamus: 13 nTPM
thalamus: 12 nTPM
pons: 12 nTPM
midbrain: 12 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0.07
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity

Cellular components

mitochondrial membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFI27L1 as an antibody target. Whether an autoantibody or antibody against IFI27L1 could matter depends on whether native IFI27L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFI27L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IFI27L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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