IER5L
Immediate early response gene 5-like protein
Also known as: bA247A12.2, IER5L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T953
- Gene
- IER5L
- Ensembl
- ENSG00000188483
- Chromosome
- 9
- Canonical length
- 404 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
No narrative summary is available for IER5L in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
404 residues, UniProt reviewed canonical sequence.
>Q5T953|IER5L
1 MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ
61 QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPAARHQ LHQLHQLHQL
121 HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA GALSELPGCA ALQPPHGAPH RGQPLEPLQP
181 GPAPLPLPLP PPAPAALCPR DPRAPAACSA PPGAAPPAAA ASPPASPAPA SSPGFYRGAY
241 PTPSDFGLHC SSQTTVLDLD THVVTTVENG YLHQDCCASA HCPCCGQGAP GPGLASAAGC
301 KRKYYPGQEE EEDDEEDAGG LGAEPPGGAP FAPCKRARFE DFCPDSSPDA SNISNLISIF
361 GSGFSGLVSR QPDSSEQPPP LNGQLCAKQA LASLGAWTRA IVAFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IER5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.66
- Highest tissue expression
- 44 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 44 nTPM
- kidney: 32 nTPM
- cervix: 27 nTPM
- heart muscle: 22 nTPM
- adipose tissue: 20 nTPM
- vagina: 20 nTPM
Single-cell type
- endometrial stromal cells: 172 nCPM
- breast myoepithelial cells: 158 nCPM
- endometrial luminal cells: 137 nCPM
- vascular smooth muscle cells: 114 nCPM
- epididymal efferent duct absorptive cells: 107 nCPM
- pericytes: 105 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- classical monocyte: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
- memory CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- medulla oblongata: 16 nTPM
- cerebral cortex: 14 nTPM
- pons: 13 nTPM
- basal ganglia: 13 nTPM
- thalamus: 13 nTPM
- white matter: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.72
- gnomAD pLI
- 0.55
- gnomAD missense Z
- 0.57
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IER5L as an antibody target. Whether an autoantibody or antibody against IER5L could matter depends on whether native IER5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IER5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IER5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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