Seroatlas · Human Serome Atlas

IER3IP1

Immediate early response 3-interacting protein 1

Also known as: IR3IP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5U9
Gene
IER3IP1
Ensembl
ENSG00000134049
Chromosome
18
Canonical length
82 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum

OverviewNCBI Gene

This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

82 residues, UniProt reviewed canonical sequence.

>Q9Y5U9|IER3IP1
     1  MAFTLYSLLQ AALLCVNAIA VLHEERFLKN IGWGTDQGIG GFGEEPGIKS QLMNLIRSVR
    61  TVMRVPLIIV NSIAIVLLLL FG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IER3IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 29 nTPM
  • skeletal muscle: 29 nTPM
  • tongue: 20 nTPM
  • liver: 18 nTPM
  • parathyroid gland: 18 nTPM
  • adrenal gland: 16 nTPM

Single-cell type

  • gastric chief cells: 49 nCPM
  • early primary spermatocytes: 41 nCPM
  • parietal cells: 39 nCPM
  • hepatocytes: 37 nCPM
  • enterocytes: 36 nCPM
  • enteric transient amplifying cells: 24 nCPM

Immune cell

  • plasmacytoid DC: 35 nTPM
  • gdT-cell: 25 nTPM
  • T-reg: 24 nTPM
  • MAIT T-cell: 22 nTPM
  • memory CD8 T-cell: 22 nTPM
  • memory CD4 T-cell: 21 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • cerebellum: 17 nTPM
  • hypothalamus: 13 nTPM
  • pons: 13 nTPM
  • white matter: 13 nTPM
  • medulla oblongata: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IER3IP1.

Disease | AllUniProt

Conditions IER3IP1 is implicated in, by any mechanism.

  • Microcephaly, epilepsy, and diabetes syndrome 1 (MEDS1) MIM:614231

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 123 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0.02
gnomAD missense Z
-0.39
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Yos1-like
  • Yos1-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IER3IP1 as an antibody target. Whether an autoantibody or antibody against IER3IP1 could matter depends on whether native IER3IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IER3IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IER3IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IER3IP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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