Seroatlas · Human Serome Atlas

IER2

Immediate early response gene 2 protein

Also known as: ETR101, IER2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTL4
Gene: IER2
Ensembl: ENSG00000160888
Chromosome: 19
Canonical length: 223 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Implicated in colorectal cancer and hepatocellular carcinoma. Biomarker of childhood acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and melanoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

223 residues, UniProt reviewed canonical sequence.

>Q9BTL4|IER2
     1  MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA KVEALEPEVS
    61  LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE APTAEETSAC CAPRPAKVSR
   121  KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE GASSEVADRL QPPPAQAEGA FPNLARVLQR
   181  RFSGLLNCSP AAPPTAPPAC EAKPACRPAD SMLNVLVRAV VAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IER2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 260 nTPM

Expression across tissuesHPA

Tissue

skin: 260 nTPM
bone marrow: 227 nTPM
adipose tissue: 181 nTPM
fallopian tube: 173 nTPM
blood vessel: 158 nTPM
stomach: 135 nTPM

Single-cell type

breast lactating cells: 2,354 nCPM
neutrophils: 2,177 nCPM
decidual stromal cells: 2,088 nCPM
esophageal apical cells: 1,500 nCPM
endometrial luminal cells: 1,441 nCPM
breast secretory cells: 1,323 nCPM

Immune cell

neutrophil: 836 nTPM
basophil: 364 nTPM
total PBMC: 275 nTPM
eosinophil: 274 nTPM
gdT-cell: 250 nTPM
NK-cell: 215 nTPM

Brain region

cerebellum: 89 nTPM
pons: 50 nTPM
medulla oblongata: 50 nTPM
thalamus: 48 nTPM
cerebral cortex: 46 nTPM
midbrain: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.77
gnomAD missense Z: -0.53
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IER2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP2R2D

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IER2 as an antibody target. Whether an autoantibody or antibody against IER2 could matter depends on whether native IER2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IER2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IER2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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