Seroatlas · Human Serome Atlas

IDO2

Indoleamine 2,3-dioxygenase 2

Also known as: I23O2_HUMAN, INDOL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZQW0
Gene: IDO2
Ensembl: ENSG00000188676
Chromosome: 8
Canonical length: 407 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q6ZQW0|IDO2
     1  MEPHRPNVKT AVPLSLESYH ISEEYGFLLP DSLKELPDHY RPWMEIANKL PQLIDAHQLQ
    61  AHVDKMPLLS CQFLKGHREQ RLAHLVLSFL TMGYVWQEGE AQPAEVLPRN LALPFVEVSR
   121  NLGLPPILVH SDLVLTNWTK KDPDGFLEIG NLETIISFPG GESLHGFILV TALVEKEAVP
   181  GIKALVQATN AILQPNQEAL LQALQRLRLS IQDITKTLGQ MHDYVDPDIF YAGIRIFLSG
   241  WKDNPAMPAG LMYEGVSQEP LKYSGGSAAQ STVLHAFDEF LGIRHSKESG DFLYRMRDYM
   301  PPSHKAFIED IHSAPSLRDY ILSSGQDHLL TAYNQCVQAL AELRSYHITM VTKYLITAAA
   361  KAKHGKPNHL PGPPQALKDR GTGGTAVMSF LKSVRDKTLE SILHPRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IDO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

placenta: 5.2 nTPM
liver: 3.1 nTPM
kidney: 0.2 nTPM
lymph node: 0.2 nTPM
appendix: 0.1 nTPM
duodenum: 0.1 nTPM

Single-cell type

endometrial luminal cells: 317 nCPM
endometrial glandular cells: 246 nCPM
early spermatids: 68 nCPM
cdc: 52 nCPM
monocytes: 30 nCPM
endometrial ciliated cells: 26 nCPM

Immune cell

myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.46

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IDO2 as an antibody target. Whether an autoantibody or antibody against IDO2 could matter depends on whether native IDO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IDO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IDO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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