Seroatlas · Human Serome Atlas

IDI2

Isopentenyl-diphosphate delta-isomerase 2

Also known as: IDI2_HUMAN, IPPI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXS1
Gene: IDI2
Ensembl: ENSG00000148377
Chromosome: 10
Canonical length: 227 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9BXS1|IDI2
     1  MSDINLDWVD RRQLQRLEEM LIVVDENDKV IGADTKRNCH LNENIEKGLL HRAFSVVLFN
    61  TKNRILIQQR SDTKVTFPGY FTDSCSSHPL YNPAELEEKD AIGVRRAAQR RLQAELGIPG
   121  EQISPEDIVF MTIYHHKAKS DRIWGEHEIC YLLLVRKNVT LNPDPSETKS ILYLSQEELW
   181  ELLEREARGE VKVTPWLRTI AERFLYRWWP HLDDVTPFVE LHKIHRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IDI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 262 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 262 nTPM
tongue: 11 nTPM
heart muscle: 2.6 nTPM
retina: 1.1 nTPM
esophagus: 0.4 nTPM
cerebral cortex: 0.3 nTPM

Single-cell type

cardiomyocytes: 149 nCPM
myonuclei: 136 nCPM
epicardial cells: 16 nCPM
retinal ganglion cells: 12 nCPM
endometrial glandular cells: 8.6 nCPM
endometrial luminal cells: 8.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.7 nTPM
thalamus: 3.6 nTPM
cerebral cortex: 3.1 nTPM
white matter: 2.9 nTPM
hippocampal formation: 2.8 nTPM
pons: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: -0.56
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cholesterol biosynthetic process
dimethylallyl diphosphate biosynthetic process
isopentenyl diphosphate biosynthetic process
isoprenoid biosynthetic process
isopentenyl diphosphate metabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IDI2 as an antibody target. Whether an autoantibody or antibody against IDI2 could matter depends on whether native IDI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IDI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IDI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...