Seroatlas · Human Serome Atlas

IDI1

Isopentenyl-diphosphate Delta-isomerase 1

Also known as: IDI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13907
Gene: IDI1
Ensembl: ENSG00000067064
Chromosome: 10
Canonical length: 227 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q13907|IDI1
     1  MPEINTNHLD KQQVQLLAEM CILIDENDNK IGAETKKNCH LNENIEKGLL HRAFSVFLFN
    61  TENKLLLQQR SDAKITFPGC FTNTCCSHPL SNPAELEESD ALGVRRAAQR RLKAELGIPL
   121  EEVPPEEINY LTRIHYKAQS DGIWGEHEID YILLVRKNVT LNPDPNEIKS YCYVSKEELK
   181  ELLKKAASGE IKITPWFKII AATFLFKWWD NLNHLNQFVD HEKIYRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IDI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

liver: 165 nTPM
breast: 157 nTPM
bone marrow: 138 nTPM
skeletal muscle: 79 nTPM
adrenal gland: 73 nTPM
duodenum: 69 nTPM

Single-cell type

epididymal principal cells: 1,188 nCPM
breast lactating cells: 796 nCPM
esophageal apical cells: 751 nCPM
urothelial cells: 581 nCPM
neutrophils: 458 nCPM
esophageal suprabasal cells: 383 nCPM

Immune cell

basophil: 83 nTPM
neutrophil: 44 nTPM
eosinophil: 39 nTPM
non-classical monocyte: 35 nTPM
intermediate monocyte: 29 nTPM
MAIT T-cell: 29 nTPM

Brain region

pons: 71 nTPM
medulla oblongata: 64 nTPM
midbrain: 61 nTPM
hypothalamus: 60 nTPM
white matter: 59 nTPM
cerebellum: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IDI1 as an antibody target. Whether an autoantibody or antibody against IDI1 could matter depends on whether native IDI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IDI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IDI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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