Seroatlas · Human Serome Atlas

ID4

DNA-binding protein inhibitor ID-4

Also known as: bHLHb27, ID4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47928
Gene: ID4
Ensembl: ENSG00000172201
Chromosome: 6
Canonical length: 161 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. The encoded protein lacks DNA binding ability, and instead regulates gene expression through binding to and inhibiting basic helix-loop-helix transcription factors. This protein has been implicated in the regulation of diverse cellular processes that play a role in development and tumorigenesis. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>P47928|ID4
     1  MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP
    61  ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP
   121  PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ID4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 258 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 258 nTPM
blood vessel: 131 nTPM
skin: 75 nTPM
fallopian tube: 58 nTPM
basal ganglia: 56 nTPM
heart muscle: 55 nTPM

Single-cell type

fallopian secretory cells: 629 nCPM
breast secretory cells: 501 nCPM
smooth muscle cells: 468 nCPM
breast myoepithelial cells: 459 nCPM
endometrial ciliated cells: 427 nCPM
müller glia: 415 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 99 nTPM
hypothalamus: 97 nTPM
thalamus: 85 nTPM
amygdala: 75 nTPM
hippocampal formation: 70 nTPM
basal ganglia: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.03
gnomAD missense Z: -0.86
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ID4 as an antibody target. Whether an autoantibody or antibody against ID4 could matter depends on whether native ID4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ID4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ID4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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