ICMT

Protein identityUniProt · HPA

UniProt accession

O60725

Gene

ICMT

Ensembl

ENSG00000116237

Chromosome

1

Canonical length

284 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

284 residues, UniProt reviewed canonical sequence.

>O60725|ICMT
     1  MAGCAARAPP GSEARLSLAT FLLGASVLAL PLLTRAGLQG RTGLALYVAG LNALLLLLYR
    61  PPRYQIAIRA CFLGFVFGCG TLLSFSQSSW SHFGWYMCSL SLFHYSEYLV TAVNNPKSLS
   121  LDSFLLNHSL EYTVAALSSW LEFTLENIFW PELKQITWLS VTGLLMVVFG ECLRKAAMFT
   181  AGSNFNHVVQ NEKSDTHTLV TSGVYAWFRH PSYVGWFYWS IGTQVMLCNP ICGVSYALTV
   241  WRFFRDRTEE EEISLIHFFG EEYLEYKKRV PTGLPFIKGV KVDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

8

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

77 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.45

gnomAD pLI

0.79

gnomAD missense Z

2.42

DepMap mean gene effect

-0.22

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• C-terminal protein methylation
• protein modification process
• protein targeting to membrane
• S-adenosylhomocysteine metabolic process
• S-adenosylmethioninamine metabolic process

Molecular functions

• protein C-terminal carboxyl O-methyltransferase activity
• protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• membrane

Protein domainsUniProt · Pfam · InterPro

• Isoprenylcysteine carboxyl methyltransferase
• Protein-S-isoprenylcysteine O-methyltransferase
• Isoprenylcysteine carboxyl methyltransferase (ICMT) family

KeywordsUniProt

• Endoplasmic reticulum
• Membrane
• Methyltransferase
• S-adenosyl-L-methionine
• Transferase
• Transmembrane
• Transmembrane helix