IAPP

Protein identityUniProt · HPA

UniProt accession

P10997

Gene

IAPP

Ensembl

ENSG00000121351

Chromosome

12

Canonical length

89 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Vesicles

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>P10997|IAPP
     1  MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV HSSNNFGAIL
    61  SSTNVGSNTY GKRNAVEVLK REPLNYLPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IAPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.56

Highest tissue expression

157 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IAPP.

Disease | ImmuneIEDB

Conditions an epitope on IAPP was assayed in.

• type 1 diabetes mellitus B and T cell
• type 2 diabetes mellitus B cell

ReferencesPubMed · IEDB

Publications for IAPP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.93

gnomAD pLI

0

gnomAD missense Z

0.2

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amylin receptor 1 signaling pathway
• amylin receptor 2 signaling pathway
• amylin receptor 3 signaling pathway
• amylin receptor signaling pathway
• apoptotic process
• bone resorption
• cell-cell signaling
• eating behavior
• negative regulation of amyloid fibril formation
• negative regulation of bone resorption
• negative regulation of osteoclast differentiation
• negative regulation of protein-containing complex assembly
• osteoclast differentiation
• positive regulation of apoptotic process
• positive regulation of calcium-mediated signaling
• positive regulation of cAMP/PKA signal transduction
• positive regulation of MAPK cascade
• sensory perception of pain
• signal transduction

Molecular functions

• amyloid-beta binding
• hormone activity
• identical protein binding
• lipid binding
• receptor ligand activity
• signaling receptor binding

Cellular components

• extracellular region
• extracellular space
• neuronal cell body

Protein domainsUniProt · Pfam · InterPro

• Calcitonin peptide-like
• Calcitonin, conserved site
• Calcitonin/adrenomedullin
• Calcitonin-like
• Calcitonin / CGRP / IAPP family
• Islet amyloid polypeptide

KeywordsUniProt

• Amidation
• Amyloid
• Cleavage on pair of basic residues
• Disulfide bond
• Hormone
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IAPP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IDE
• INS