IAH1
Isoamyl acetate-hydrolyzing esterase 1 homolog
Also known as: IAH1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2TAA2
- Gene
- IAH1
- Ensembl
- ENSG00000134330
- Chromosome
- 2
- Canonical length
- 248 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within gene expression. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
248 residues, UniProt reviewed canonical sequence.
>Q2TAA2|IAH1
1 MALCEAAGCG SALLWPRLLL FGDSITQFSF QQGGWGASLA DRLVRKCDVL NRGFSGYNTR
61 WAKIILPRLI RKGNSLDIPV AVTIFFGAND SALKDENPKQ HIPLEEYAAN LKSMVQYLKS
121 VDIPENRVIL ITPTPLCETA WEEQCIIQGC KLNRLNSVVG EYANACLQVA QDCGTDVLDL
181 WTLMQDSQDF SSYLSDGLHL SPKGNEFLFS HLWPLIEKKV SSLPLLLPYW RDVAEAKPEL
241 SLLGDGDHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IAH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 68 nTPM
Expression across tissuesHPA
Tissue
- tongue: 68 nTPM
- testis: 60 nTPM
- choroid plexus: 51 nTPM
- heart muscle: 49 nTPM
- liver: 43 nTPM
- parathyroid gland: 42 nTPM
Single-cell type
- late spermatids: 757 nCPM
- oocytes: 718 nCPM
- late primary spermatocytes: 542 nCPM
- early spermatids: 420 nCPM
- epicardial cells: 371 nCPM
- extravillous trophoblasts: 144 nCPM
Immune cell
- plasmacytoid DC: 52 nTPM
- myeloid DC: 50 nTPM
- T-reg: 46 nTPM
- non-classical monocyte: 44 nTPM
- classical monocyte: 39 nTPM
- memory B-cell: 38 nTPM
Brain region
- choroid plexus: 37 nTPM
- cerebellum: 35 nTPM
- white matter: 34 nTPM
- cerebral cortex: 33 nTPM
- hypothalamus: 32 nTPM
- pons: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.91
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.29
- DepMap mean gene effect
- 0.18
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- GDSL lipase/esterase
- SGNH hydrolase superfamily
- GDSL-like Lipase/Acylhydrolase
- Isoamyl acetate-hydrolyzing esterase Iah1-like
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IAH1 as an antibody target. Whether an autoantibody or antibody against IAH1 could matter depends on whether native IAH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IAH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IAH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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