Seroatlas · Human Serome Atlas

HYCC2

Hyccin 2

Also known as: FAM126B, HYCC2_HUMAN, MGC39518

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXS8
Gene: HYCC2
Ensembl: ENSG00000155744
Chromosome: 2
Canonical length: 530 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol and membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q8IXS8|HYCC2
     1  MLGTDRCVVE EWLSEFKALP DTQITSYAAT LHRKKTLVPA LYKVIQDSNN ELLEPVCHQL
    61  FELYRSSEVR LKRFTLQFLP ELMWVYLRLT VSRDRQSNGC IEALLLGIYN LEIADKDGNN
   121  KVLSFTIPSL SKPSIYHEPS TIGSMALTEG ALCQHDLIRV VYSDLHPQRE TFTAQNRFEV
   181  LSFLMLCYNS AIVYMPASSY QSLCRMGSRV CVSGFPRQHE KHWKELCGRI VLDPEFMVQL
   241  LTGVYYAMYN GQWDLGQEVL DDIIYRAQLE LFSQPLLVAN AMKNSLPFDA PDSTQEGQKV
   301  LKVEVTPTVP RISRTAITTA SIRRHRWRRE GAEGVNGGEE SVNLNDADEG FSSGASLSSQ
   361  PIGTKPSSSS QRGSLRKVAT GRSAKDKETA SAIKSSESPR DSVVRKQYVQ QPTDLSVDSV
   421  ELTPMKKHLS LPAGQVVPKI NSLSLIRTAS ASSSKSFDYV NGSQASTSIG VGTEGGTNLA
   481  ANNANRYSTV SLQEDRLGQA GEGKELLSPG APLTKQSRSP SFNMQLISQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HYCC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
cerebellum: 11 nTPM
retina: 10 nTPM
cerebral cortex: 8.9 nTPM
esophagus: 7.9 nTPM
adipose tissue: 7.8 nTPM

Single-cell type

neutrophils: 1,349 nCPM
cardiomyocytes: 495 nCPM
neutrophil progenitors: 296 nCPM
esophageal apical cells: 243 nCPM
sertoli cells: 209 nCPM
myonuclei: 187 nCPM

Immune cell

neutrophil: 26 nTPM
eosinophil: 6.2 nTPM
MAIT T-cell: 4 nTPM
gdT-cell: 3.8 nTPM
naive CD8 T-cell: 3.8 nTPM
memory CD4 T-cell: 3.2 nTPM

Brain region

cerebellum: 57 nTPM
cerebral cortex: 41 nTPM
white matter: 35 nTPM
basal ganglia: 34 nTPM
thalamus: 33 nTPM
hippocampal formation: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.18
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HYCC2 as an antibody target. Whether an autoantibody or antibody against HYCC2 could matter depends on whether native HYCC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HYCC2 is annotated at the cell surface, where native HYCC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HYCC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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